منابع مشابه
Meanwhile, back at the ring canal…
n page 703, Kelso et al. complete the trilogy of actin papers with a detailed biochemical analysis of the Drosophila Kelch protein. Like the Arp2/3 complex, Kelch is required for proper actin organization in ovarian ring canals. Although the structure of Kelch suggested that it might act as a dimeric actin cross-linking protein, this activity had not yet been demonstrated. In an impressive seri...
متن کاملHepatology Elsewhere
The pathogenesis of nonalcoholic steatohepatitis (NASH) is poorly defined. Feeding mice a diet deficient in methionine and choline (MCD diet) induces experimental NASH. Osteopontin (OPN) is a Th1 cytokine that plays an important role in several fibroinflammatory diseases. We examined the role of OPN in the development of experimental NASH. A/J mice were fed MCD or control diet for up to 12 wk, ...
متن کاملHEPATOLOGY Elsewhere
Cholestasis, or impaired bile flow, is an important but poorly understood manifestation of liver disease. Two clinically distinct forms of inherited cholestasis, benign recurrent intrahepatic cholestasis (BRIC) and progressive familial intrahepatic cholestasis type 1 (PFIC1), were previously mapped to 18q21. Haplotype analysis narrowed the candidate region for both diseases to the same interval...
متن کاملHepatology Elsewhere
The ezrin-radixin-moesin (ERM) family of proteins crosslink actin filaments and integral membrane proteins. Radixin (encoded by Rdx) is the dominant ERM protein in the liver of wildtype mice and is concentrated at bile canalicular membranes (BCMs). Here we show that Rdx( / ) mice are normal at birth, but their serum concentrations of conjugated bilirubin begin to increase gradually around 4 wee...
متن کاملIdentity in Physics and Elsewhere
Is identity a fundamental concept? Of course, it all depends on what it takes for something to be fundamental. For the purposes of this paper, I will consider identity’s fundamentality as exhibiting four features, which, if satisfied, also provide four reasons to think that a fundamental concept is involved (see Bueno [2014]): (1) Identity is presupposed in every conceptual system; (2) it is re...
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ژورنال
عنوان ژورنال: Nature
سال: 1996
ISSN: 0028-0836,1476-4687
DOI: 10.1038/379395a0